Murphy's theatrical debut, Gorillas in the Mist, was nominated for an Academy Award for his writing. In 1995, Murphy made his directorial debut with Last of the Dogmen and wrote the feature. Afterwards, Murphy has spent nearly ten years with The Walt Disney Company writing The Hunchback of Notre Dame in 1996, Tarzan in 1999, Atlantis: The Lost Empire in 2001, and Brother Bear in 2003. During his time with Disney, he was hired by TriStar Pictures to write a treatment to a planned sequel to the 1998 film Godzilla. But due to negative reviews from critics and audiences alike, the planned sequel was cancelled. After working with Disney for a few years, he then left the company in 2006 and went to work at Warner Bros. Animation for a couple years. His work includes Superman/Batman: Apocalypse and Batman: Year One, and he wrote several episodes for the 2011 Thundercats reboot, Teen Titans Go! and Be Cool, Scooby-Doo!. While at Warner Bros., Murphy wrote the direct-to-video 3D thriller film Dark Country for Sony Pictures and Stage 6 Films, based on a short story written by Murphy, and directed by Thomas Jane. He was attached to write an animated feature directed by Kirk Wise called Galaxy Gas, and a TV pilot that was sold to Legendary Pictures. Towards the end of the 2010s, Murphy became involved as a writer of two crowdsourced short films: The Haunted Swordsman and The Passengers, based on the Stephen King short story Rest Stop.] In June 2020, Murphy became attached to write a reimagining of the 1980 horror film The Changeling.
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